Research & Development
Addressing Major Worldwide Health Concerns
Our goal is to design drugs against all subtypes of a given virus.
Globally, there are 130-150 million people with chronic hepatitis C infection.1 It is estimated that 500,000 people die annually from liver diseases related to hepatitis C.2
All populations can be seriously affected by annual influenza outbreaks but certain subpopulations have a greater risk of complications such as children < 2 years, adults ≥ 65 years, pregnant women, and people of any age with certain medical conditions or weakened immune systems. Globally, on an annual basis, influenza is estimated to result in about 3 to 5 million cases of severe illness, and about 250,000 to 500,000 deaths.3
Norovirus is the leading cause of acute gastroenteritis worldwide.4 Annually in the US, norovirus causes 19–21 million cases of acute gastroenteritis and contributes to about 56,000–71,000 hospitalizations and 570-800 deaths, mostly among young children and the elderly.5
Our proprietary technologies revolve around a structure-based drug discovery strategy paired with comprehensive nucleoside inhibitor discovery experience. Using techniques called protein cocrystallization and X-ray crystallography, we rapidly identify novel binding sites, identify critical inhibitor-protein interactions and optimize the structure of the inhibitor in a highly rapid iterative fashion.
- "Hepatitis C." WHO. Web. 30 July 2015. <http://www.who.int/
- Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2095-2128. <http://www.who.int/
- "Influenza (Seasonal)." WHO. Web. 30 July 2015. <http://www.who.int/
- "Norovirus Worldwide." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 05 Dec. 2014. Web. 30 July 2015. <http://www.cdc.gov/norovirus/
- "U.S. Trends and Outbreaks." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 30 Dec. 2014. Web. 30 July 2015. <http://www.cdc.gov/norovirus/