Noro Polymerase Inhibitor

Program Discovery Preclinical Phase 1 Phase 2 Phase 3
Norovirus Noro Polymerase Inhibitor
Discovery Phase in progress
Preclinical Phase not started
Phase 1 Phase not started
Phase 2 Phase not started
Phase 3 Phase not started

We are developing inhibitors of the RNA-dependent RNA polymerase of norovirus. Similar to the hepatitis C virus polymerases, this enzyme is essential to viral replication and is highly conserved between all noroviral geno-groups. Therefore, an inhibitor of this enzyme might be an effective treatment or short-term prophylactic agent when administered during a cruise or hospital/nursing home stay, for example. We are currently developing polymerase inhibitors, Nuc and NNIs using X-ray quality norovirus polymerase crystals.